Enhanced biocompatibility and antibacterial property of polyurethane materials modified with citric acid and chitosan

Autor:	Tian-Ming Liu, Yun-Ren Qiu, Xing-Ze Wu
Rok vydání:	2016
Předmět:	Adult Blood Platelets Materials science Biocompatibility Polyurethanes Biomedical Engineering Biophysics Bioengineering Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Hemolysis Citric Acid Biomaterials Chitosan chemistry.chemical_compound Adsorption Platelet Adhesiveness Polymer chemistry Materials Testing Humans Pseudomonas Infections Blood Coagulation Polyurethane technology industry and agriculture 021001 nanoscience & nanotechnology Isocyanate 0104 chemical sciences Anti-Bacterial Agents Membrane chemistry Pseudomonas aeruginosa 0210 nano-technology Citric acid Protein adsorption Nuclear chemistry
Zdroj:	Journal of biomaterials science. Polymer edition. 27(12)
ISSN:	1568-5624
Popis:	Citric acid (CA) and chitosan (CS) were covalently immobilized on polyurethane (PU) materials to improve the biocompatibility and antibacterial property. The polyurethane pre-polymer with isocyanate group was synthesized by one pot method, and then grafted with citric acid, followed by blending with polyethersulfone (PES) to prepare the blend membrane by phase-inversion method so that chitosan can be grafted from the membrane via esterification and acylation reactions eventually. The native and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectroscope, X-ray photoelectron spectroscopy, scanning electron microscopy, water contact angle measurement, and tensile strength test. Protein adsorption, platelet adhesion, hemolysis assay, activated partial thromboplastin time, prothrombin time, thrombin time, and adsorption of Ca(2+) were executed to evaluate the blood compatibility of the membranes decorated by CA and CS. Particularly, the antibacterial activities on the modified membranes were evaluated based on a vitro antibacterial test. It could be concluded that the modified membrane had good anticoagulant property and antibacterial property.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6a4fb02445517a5aadc0ac5ad3f0d9 https://pubmed.ncbi.nlm.nih.gov/27267435 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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