A comparative proteome analysis of hippocampal tissue from schizophrenic and Alzheimer's disease individuals
| Autor: | Brian Dean, Richard L.M. Faull, Paul F. Edgar, Garth J. S. Cooper, Robert R. Kydd, Sarah J. Schönberger |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Hippocampus Nerve Tissue Proteins Hippocampal formation Biology Cellular and Molecular Neuroscience Degenerative disease Alzheimer Disease Internal medicine medicine Humans Electrophoresis Gel Two-Dimensional Molecular Biology Aged Diazepam Binding Inhibitor Two-dimensional gel electrophoresis Genome Human Nervous tissue Age Factors Middle Aged medicine.disease Psychiatry and Mental health Endocrinology medicine.anatomical_structure Postmortem Changes Proteome Schizophrenia Autopsy Alzheimer's disease Carrier Proteins Diazepam binding inhibitor |
| Zdroj: | Molecular Psychiatry. 4:173-178 |
| ISSN: | 1476-5578 1359-4184 |
| Popis: | The proteins expressed by a genome have been termed the proteome. Comparative proteome analysis of brain tissue offers a novel means to identify biologically significant gene products that underlie psychopathology. In this study we collected post mortem hippocampal tissue from the brains of seven schizophrenic, seven Alzheimer's disease (AD) and seven control individuals. Hippocampal proteomes were visualised by two-dimensional gel electrophoresis of homogenised tissue. A mean of 549 (s.d. 35) proteins were successfully matched between each disease group and the control group. In comparison with the control hippocampal proteome, eight proteins in the schizophrenic hippocampal proteome were found to be decreased and eight increased in concentration, whereas, in the AD hippocampal proteome, 35 proteins were decreased and 73 were increased in concentration (P |
| Databáze: | OpenAIRE |
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