Destruction of the noradrenergic system with DSP4 potentiates the behavioral effects of MK-801 in rats

Autor: Izzettin Hatip-Al-Khatib, Funda Bolukbasi
Rok vydání: 1999
Předmět:
Male
Benzylamines
Clinical Biochemistry
Hyperlocomotor activity
Toxicology
Biochemistry
DSP4
noradrenergic system
Behavioral Neuroscience
Sniffing
dizocilpine
rat
MK-801
circling behavior
Behavior
Animal
Chemistry
Glutamate receptor
article
Drug Synergism
locomotion
priority journal
NMDA receptor
medicine.symptom
medicine.drug
medicine.medical_specialty
Ataxia
animal experiment
stereotypy
Motor Activity
2 bromo n (2 chloroethyl) n ethylbenzylamine
Norepinephrine
Adrenergic Agents
Internal medicine
medicine
Animals
controlled study
Rats
Wistar
Biological Psychiatry
Pharmacology
nonhuman
behavior
ataxia
rearing
Rats
Dizocilpine
Stereotypy (non-human)
Endocrinology
intraperitoneal drug administration
Catecholamine
Noradrenaline
Dizocilpine Maleate
Stereotyped Behavior
Adrenergic Agents/*pharmacology
Ataxia/chemically induced
Behavior
Animal/*drug effects
Benzylamines/*pharmacology
Dizocilpine Maleate/*pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Motor Activity/drug effects
Stereotyped Behavior/drug effects
Excitatory Amino Acid Antagonists
Zdroj: Pharmacology, biochemistry, and behavior. 62(2)
ISSN: 0091-3057
Popis: In this study we investigated the effect of lesioning the noradrenergic systems on the behavioral effects of (5R, 10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5,10-imine hydrogen maleate-MK-801, in rats. The noradrenergic system was lesioned with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride-DSP4 (60 mg/kg IP). MK-801 increased the locomotor activity and rearing. DSP4 significantly further increased the hyperlocomotor activity, circling (especially to the left side), sniffing, rolling, and falling that were induced by MK-801. These results showed that destruction of the noradrenergic system increased MK-801-hyperlocomotor activity, ataxia and stereotypy. Copyright (C) 1999 Elsevier Science Inc.
Databáze: OpenAIRE
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