Opiate-Antagonist Reversal of Neurological Deficits –Experimental and Clinical Studies–
| Autor: | Takao Wani, Yoichiro Namba, Tetsuya Masaoka, Shimpei Namba, Shinichi Nishigaki, Noriaki Fujiwara |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Levallorphan Narcotic Antagonists Ischemia Chick Embryo (+)-Naloxone Brain Ischemia Arousal Dogs medicine Animals Humans Aged Naloxone Narcotic antagonist General Neuroscience Antagonist General Medicine Middle Aged medicine.disease Disease Models Animal Psychiatry and Mental health Neurology Cerebral blood flow Cerebrovascular Circulation Anesthesia Injections Intravenous Cats Female Neurology (clinical) Nervous System Diseases Opiate Tomography X-Ray Computed Psychology Blood Flow Velocity medicine.drug |
| Zdroj: | Psychiatry and Clinical Neurosciences. 40:61-79 |
| ISSN: | 1440-1819 1323-1316 |
| Popis: | The proximal left M1 and the common trunk of A2 were clipped in 12 adult dogs. Naloxone was injected after placing the clips onto 6 dogs. Neither the systemic blood pressure nor the local cerebral blood flow were influenced by naloxone. In another group of 6 dogs with chronic right hemiplegia, naloxone proved passably effective in improving the hemiplegia. Eight patients with neurological deficits of various etiologies were administered levallorphan. The improvement in motor performance and/or elevation of mental activity was observed more or less in all but 2 of the patients. It was considered that the effect of opiate antagonists is based partially on the facilitation of synaptic transmission exaggerated by the arousal response. |
| Databáze: | OpenAIRE |
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