Lack of favorable effect of immunomodulators on outbred syngeneic rodent islet transplantation
| Autor: | K. Ishihara, Yoshihiko Ishida, Kazushige Ejiri, J.H. Tsai, Yuki Yamashiro, Shigeaki Baba, Yasuo Morimoto, S.J. Shin, N. Kuroda, Hiroshi Taniguchi, Y. Hara |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Rodent Endocrinology Diabetes and Metabolism medicine.medical_treatment Islets of Langerhans Transplantation Lobenzarit Diabetes Mellitus Experimental Picibanil Endocrinology Adjuvants Immunologic Diabetes mellitus Internal medicine biology.animal Internal Medicine medicine Animals Insulin ortho-Aminobenzoates Saline geography Biological Products geography.geographical_feature_category biology business.industry Graft Survival Rats Inbred Strains General Medicine medicine.disease Streptozotocin Islet Rats Transplantation Transplantation Isogeneic Liver business medicine.drug |
| Zdroj: | Diabetes research and clinical practice. 8(2) |
| ISSN: | 0168-8227 |
| Popis: | We studied the effect of two immunomodulators, lobenzarit disodium and OK-432, on outbred syngeneic islet transplantation. Six hundred fresh islets taken from two male Wistar rats were transplanted intraportally into other male Wistar rats that had been made diabetic with streptozotocin. Lobenzarit was given to 12 recipients and OK-432 to seven recipients intraperitoneally for 1 month, while nine controls received only intraperitoneal saline. Both drug-treated groups could not maintain lower fasting plasma glucose levels or higher fasting body weights at each time as compared with controls. The islet survival time in lobenzarit-treated (23.5 ± 8.0 days) and OK-432-treated (25.3 ± 13.4 days) groups was not longer than that (21.6 ± 9.4 days) of the control group. All the pancreatic insulin contents of the seven surviiing controls, ten surviving lobenzarit and five surviving OK-432 recipients were less than 0.8% of the mean insulin content obtained from 12 normal male rats. The hepatic insulin content of both drug-treated groups was not higher than that of the control group. These results suggest that lobenzarit disodium and OK-432 cannot protect outbred syngeneic islet grafts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|