A Genetic Variant of the BTLA Gene is Related to Increased Risk and Clinical Manifestations of Breast Cancer in Chinese Women
| Autor: | Linlin Zhen, Jian-hua Shi, Rui-Peng Zhao, Wei Song, Chang Li, Kang Xu, Zhi Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty BTLA Breast Neoplasms Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Breast cancer Asian People Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Receptors Immunologic Gene business.industry Case-control study Genetic variants Middle Aged medicine.disease 030104 developmental biology Increased risk 030220 oncology & carcinogenesis Lymphocyte activation Female business |
| Zdroj: | Clinical Breast Cancer. 21:e512-e517 |
| ISSN: | 1526-8209 |
| DOI: | 10.1016/j.clbc.2020.12.009 |
| Popis: | B and T lymphocyte attenuator (BTLA), an immunoinhibitory receptor, is shown to suppress the lymphocyte activation. Several studies addressed the relationship between the BTLA rs1982809 polymorphism and the risk of cancer.To identify the effects of this polymorphism on the risk of breast cancer (BC), this study examined Chinese women from China, Jiangsu Province. This study involved 324 patients with BC and 412 controls.We observed that the BTLA rs1982809 polymorphism elevated the risk of BC. A similar finding was also shown in the subgroups of premenopausal women and those aged 55 years old. In addition, this polymorphism was correlated with the estrogen receptor status, C-erbB-2 status, Ki-67 status, TNM stage, and tumor size of patients with BC.Collectively, the BTLA rs1982809 polymorphism shows a significant association with elevated risk and clinical features of BC in Chinese women. Further studies involving other races are urgently needed to replicate these findings. |
| Databáze: | OpenAIRE |
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