Scaling up interventions to achieve global tuberculosis control: progress and new developments

Autor: Ben J. Marais, Katherine Floyd, Steve Graham, Stewart T. Cole, Anthony D. Harries, Alimuddin Zumla, Karin Weyer, Giovanni Battista Migliori, Stefan H. E. Kaufmann, Haileyesus Getahun, Knut Lönnroth, Christian Lienhardt, Paul Nunn, Mario C. Raviglione, Jeremiah Chakaya
Rok vydání: 2012
Předmět:
Biomedical Research
Antitubercular Agents
Psychological intervention
Vulnerability
Xpert Mtb/Rif Test
HIV Infections
Global Health
0302 clinical medicine
Tuberculosis
Multidrug-Resistant

Prevalence
Global health
Isoniazid Preventive Therapy
Community Health Services
030212 general & internal medicine
Tuberculosis Vaccines
Antituberculosis Drugs
0303 health sciences
biology
Incidence
Financing
Organized

1. No poverty
General Medicine
3. Good health
Mycobacterium-Tuberculosis
General partnership
Hiv-Infected Adults
Tuberculosis vaccines
Intrathoracic Tuberculosis
medicine.medical_specialty
Tuberculosis
Antiretroviral Therapy
Mycobacterium tuberculosis
Pulmonary Tuberculosis
03 medical and health sciences
Development economics
medicine
Humans
Noncommunicable Diseases
030304 developmental biology
business.industry
Social Support
biology.organism_classification
medicine.disease
Surgery
Communicable Disease Control
Drug-Resistant Tuberculosis
Portfolio
business
Biomarkers
Forecasting
Zdroj: The Lancet
ResearcherID
The Lancet; Vol 379
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(12)60727-2
Popis: Tuberculosis is still one of the most important causes of death worldwide. The 2010 Lancet tuberculosis series provided a comprehensive overview of global control efforts and challenges. In this update we review recent progress. With improved control efforts, the world and most regions are on track to achieve the Millennium Development Goal of decreasing tuberculosis incidence by 2015, and the Stop TB Partnership target of halving 1990 mortality rates by 2015; the exception is Africa. Despite these advances, full scale-up of tuberculosis and HIV collaborative activities remains challenging and emerging drug-resistant tuberculosis is a major threat. Recognition of the effect that non-communicable diseases--such as smoking-related lung disease, diet-related diabetes mellitus, and alcohol and drug misuse--have on individual vulnerability, as well as the contribution of poor living conditions to community vulnerability, shows the need for multidisciplinary approaches. Several new diagnostic tests are being introduced in endemic countries and for the first time in 40 years a coordinated portfolio of promising new tuberculosis drugs exists. However, none of these advances offer easy solutions. Achievement of international tuberculosis control targets and maintenance of these gains needs optimum national health policies and services, with ongoing investment into new approaches and strategies. Despite growing funding in recent years, a serious shortfall persists. International and national financial uncertainty places gains at serious risk. Perseverance and renewed commitment are needed to achieve global control of tuberculosis, and ultimately, its elimination.
Databáze: OpenAIRE