Pre- and post-translational regulation of osteopontin in cancer

Autor:	Pieter H. Anborgh, Jennifer C. Mutrie, Ann F. Chambers, Alan B. Tuck
Rok vydání:	2011
Předmět:	biology CD44 Integrin Matricellular protein Alternative splicing Inflammation Review Cell Biology medicine.disease Biochemistry Metastasis stomatognathic system Translational regulation biology.protein medicine Cancer research Osteopontin medicine.symptom Molecular Biology
Zdroj:	Journal of Cell Communication and Signaling. 5:111-122
ISSN:	1873-961X 1873-9601
DOI:	10.1007/s12079-011-0130-6
Popis:	Osteopontin (OPN) is a matricellular protein that binds to a number of cell surface receptors including integrins and CD44. It is expressed in many tissues and secreted into body fluids including blood, milk and urine. OPN plays important physiological roles in bone remodeling, immune response and inflammation. It is also a tumour-associated protein, and elevated OPN levels are associated with tumour formation, progression and metastasis. Research has revealed a promising role for OPN as a cancer biomarker. OPN is subject to alternative splicing, as well as post-translational modifications such as phosphorylation, glycosylation and proteolytic cleavage. Functional differences have been revealed for different isoforms and post-translational modifications. The pattern of isoform expression and post-translational modification is cell-type specific and may influence the potential role of OPN in malignancy and as a cancer biomarker.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5fa38fe2e3b6fecb078eaf4447d650 https://doi.org/10.1007/s12079-011-0130-6 Zobrazit plný text záznamu Full text from SpringerLink