Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine

Autor: Alexander P. J. Vlaar, Joanna C. Dionne, Sanne de Bruin, Marije Wijnberge, S. Jorinde Raasveld, Frank E. H. P. van Baarle, Massimo Antonelli, Cecile Aubron, Jacques Duranteau, Nicole P. Juffermans, Jens Meier, Gavin J. Murphy, Riccardo Abbasciano, Marcella C. A. Müller, Marcus Lance, Nathan D. Nielsen, Herbert Schöchl, Beverley J. Hunt, Maurizio Cecconi, Simon Oczkowski
Přispěvatelé: Intensive Care Medicine, AII - Inflammatory diseases, ACS - Microcirculation, Graduate School, ACS - Pulmonary hypertension & thrombosis, Anesthesiology, ACS - Heart failure & arrhythmias, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Intensive Care Medicine
Intensive care medicine, 47(12), 1368-1392. Springer Verlag
ISSN: 1432-1238
0342-4642
Popis: Purpose To develop evidence-based clinical practice recommendations regarding transfusion practices and transfusion in bleeding critically ill adults. Methods A taskforce involving 15 international experts and 2 methodologists used the GRADE approach to guideline development. The taskforce addressed three main topics: transfusion support in massively and non-massively bleeding critically ill patients (transfusion ratios, blood products, and point of care testing) and the use of tranexamic acid. The panel developed and answered structured guideline questions using population, intervention, comparison, and outcomes (PICO) format. Results The taskforce generated 26 clinical practice recommendations (2 strong recommendations, 13 conditional recommendations, 11 no recommendation), and identified 10 PICOs with insufficient evidence to make a recommendation. Conclusions This clinical practice guideline provides evidence-based recommendations for the management of massively and non-massively bleeding critically ill adult patients and identifies areas where further research is needed. Supplementary Information The online version contains supplementary material available at 10.1007/s00134-021-06531-x.
Databáze: OpenAIRE
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