Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests
| Autor: | Eckhard Mayer, Balthasar Eberle, Joerg Schmiedeskamp, Andreas E. Morbach, Julia Zaporozhan, Sebastian Ley, Hans-Ulrich Kauczor, Wolfgang Schreiber, K. K. Gast, Claus Peter Heussel, A. Stepniak, Alexander Biedermann |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty High-resolution computed tomography Helium Pulmonary function testing Isotopes medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Functional evaluation medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Middle Aged respiratory system Single Lung Transplantation Magnetic Resonance Imaging Respiratory Function Tests respiratory tract diseases Lung density Pulmonary Emphysema Concomitant Female Radiology Tomography X-Ray Computed business Nuclear medicine Lung Transplantation |
| Zdroj: | Investigative Radiology. 39:427-434 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/01.rli.0000129468.79005.1d |
| Popis: | Purpose: To assess the emphysematous enlargement of distal air-spaces and concomitant large and small airway disease using diffusion-weighted 3 Helium-magnetic resonance imaging (MRI), high-resolution computed tomography (HRCT), and lung function tests (LFT). Methods: Seven patients were examined after single lung transplantation (LTx) and 1 before double LTx for various forms of emphysema. Five patients after double LTx served as controls. Patients were assessed by 3 Helium-MRI (apparent diffusion coefficient [ADC]), HRCT (mean lung density [MLD], emphysema index [El]), and LFT. Results: Transplanted lungs: mean ADC = 0.17 cm 2 /s, MLD = -848 H, El = 22%. Emphysematous lungs: mean ADC = 0.33 cm 2 /s, MLD = -922 H; EI = 54%. Good correlations were found between ADC and MLD (r = 0.6), EI (r = 0.8), intrathoracic gas volume (r = 0.7), forced expiratory volume in I second (r = 0.7), and forced expiratory flows (r = 0.7). In contrast, HRCT only provided moderate correlations with LFT (El: r = 0.5; MLD: r [le] 0.4). Conclusion: In this initial study, 3 He-MRI yield good correlations with HRCT and agrees better than HRCT with the functional characterization of emphysema regarding hyperinflation, large and small airway disease as provided by LFT. |
| Databáze: | OpenAIRE |
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