Persistent inflammation and anemia among critically ill septic patients
Autor: | Azra Bihorac, Julie A. Stortz, Frederick A. Moore, Tezcan Ozrazgat-Baslanti, Tyler J. Loftus, Scott C. Brakenridge, Christiaan Leeuwenburgh, Alicia M. Mohr, Philip A. Efron, Babette Brumback, Zhongkai Wang, Gabriella Ghita, Juan C. Mira, Ricardo Ungaro, Lyle L. Moldawer |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Anemia Critical Illness MEDLINE Critical Care and Intensive Care Medicine Article Proinflammatory cytokine Persistent inflammation 03 medical and health sciences 0302 clinical medicine Cytokines metabolism Sepsis hemic and lymphatic diseases Internal medicine Humans Medicine Prospective Studies Prospective cohort study Erythropoietin Aged Inflammation business.industry Critically ill 030208 emergency & critical care medicine Middle Aged medicine.disease Cytokines Female Surgery business medicine.drug |
Zdroj: | Journal of Trauma and Acute Care Surgery. 86:260-267 |
ISSN: | 2163-0763 2163-0755 |
Popis: | Associations among inflammatory cytokines, erythropoietin (EPO), and anemia in critically ill septic patients remain unclear. This study tested the hypothesis that elevated inflammatory cytokines and decreased EPO would be associated with iron-restricted anemia while accounting for operative blood loss, phlebotomy blood loss, and red blood cell (RBC) transfusion volume.Prospective observational cohort study of 42 critically ill septic patients was conducted. Hemoglobin (Hb) at sepsis onset and hospital discharge were used to calculate ΔHb. Operative blood loss, phlebotomy blood loss, and RBC transfusion volume were used to calculate adjusted ΔHb (AdjΔHb) assuming that 300 mL RBC is equal to 1 g/dL Hb. Patients with AdjΔHb of greater than 0 (positive AdjΔHb, n = 18) were compared with patients with AdjΔHb of less than or equal to 0 (negative AdjΔHb, n = 24).Plasma tumor necrosis factor α, granulocyte colony-stimulating factor, interleukin (IL)-6, IL-8, EPO, erythrocyte mean corpuscular volume, and serum transferrin receptor were measured on days 0, 1, 4, 7, and 14. Patients with negative AdjΔHb had significantly higher day 14 levels of IL-6 (37.4 vs. 15.2 pg/mL, p0.05), IL-8 (39.1 vs. 18.2 pg/mL, p = 0.01), and granulocyte colony-stimulating factor (101.3 vs. 60.5 pg/mL, p = 0.01), but not EPO. On linear regression analysis, lower AdjΔHb was associated with higher day 14 levels of IL-6 (r = 0.22, p0.01), IL-8 (r = 0.10, p = 0.04), stromal cell-derived factor 1 (r = 0.14, p = 0.02), and tumor necrosis factor α (r = 0.13, p = 0.02), but not EPO. Patients with negative AdjΔHb had significantly lower mean corpuscular volume on days 4 (89.6 vs. 93.2 fL/cell, p = 0.04), 7 (92.3 vs. 94.9 fL/cell, p = 0.04), and 14 (92.1 vs. 96.0 fL/cell, p = 0.03) but similar serum transferrin receptor levels.Persistent elevation of inflammatory cytokines was associated with iron-restricted anemia among critically ill septic patients, occurring in the absence of systemic iron deficiency, independent of endogenous EPO.Prognostic study, level II. |
Databáze: | OpenAIRE |
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