Synthesis of betulinic acid derivatives with activity against human melanoma
| Autor: | John M. Pezzuto, Emily Pisha, Darrick S. H. L. Kim |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Carboxylic acid
Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Biochemistry Chemical synthesis chemistry.chemical_compound Betulinic acid Drug Discovery medicine Humans Betulinic Acid Cytotoxicity Melanoma neoplasms Molecular Biology chemistry.chemical_classification Chemistry Organic Chemistry Hydrogen Bonding medicine.disease Triterpenes In vitro Epidermoid carcinoma Cell culture Carcinoma Squamous Cell Molecular Medicine Mouth Neoplasms Drug Screening Assays Antitumor Pentacyclic Triterpenes |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 8:1707-1712 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(98)00295-9 |
| Popis: | Betulinic acid has been modified at C-3, C-20, and C-28 positions and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. This preliminary investigation demonstrates that simple modifications of the parent structure of betulinic acid can produce potentially important derivatives, which may be developed as antitumor drugs. |
| Databáze: | OpenAIRE |
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