Reversible Stabilization of Transition-Metal-Binding DNA G-Quadruplexes
| Autor: | Guido H. Clever, Roberta Pievo, David M. Engelhard |
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| Rok vydání: | 2013 |
| Předmět: |
Models
Molecular Circular dichroism Inorganic chemistry Ethylenediaminetetraacetic acid 010402 general chemistry G-quadruplex 01 natural sciences Catalysis law.invention Metal chemistry.chemical_compound Drug Stability Transition metal Nickel law Pyridine Transition Elements Electron paramagnetic resonance Gel electrophoresis 010405 organic chemistry General Chemistry 0104 chemical sciences G-Quadruplexes Crystallography chemistry Metals visual_art visual_art.visual_art_medium Copper |
| Zdroj: | Angewandte Chemie-International Edition |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201307594 |
| Popis: | You can't top the CopperTop: Tetramolecular G-quadruplexes modified with terminal pyridine ligands exhibit metal-triggered stabilization as monitored by thermal denaturation studies, circular dichroism, and nondenaturing gel electrophoresis. Formation of the square-planar Cu(II) (pyridine)4 complex was confirmed by EPR measurements. The metal complexation is fully reversible by removal of the transition metal with ethylenediaminetetraacetic acid (edta). |
| Databáze: | OpenAIRE |
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