MDS shows a higher expression of hTERT and alternative splice variants in unactivated T-cells
| Autor: | Houfang Sun, Lili Yang, Xiubao Ren, Wen Dong, Pearlie K. Epling-Burnette, Lei Wu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Telomerase medicine.medical_specialty T-Lymphocytes telomerase Bioinformatics 03 medical and health sciences Internal medicine MDS Humans Medicine splice Telomerase reverse transcriptase RNA Messenger Aged Cancer immunology business.industry T-cells Myelodysplastic syndromes Cancer Middle Aged Telomere medicine.disease Alternative Splicing 030104 developmental biology hTERT alternative splice variants International Prognostic Scoring System Myelodysplastic Syndromes Female hTERT business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Wen Dong 1, * , Lei Wu 2, 3, 4, * , Houfang Sun 2, 3, 4 , Xiubao Ren 2, 3, 4 , Pearlie K. Epling-Burnette 5 , Lili Yang 2, 3, 4 1 Department of Orthopaedic Surgery, Tianjin Hongqiao Hospital, Tianjin, P.R. China 2 Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, P.R. China 3 National Clinical Research Center of Cancer, P.R. China 4 Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, P.R. China 5 Immunology Program at the H. Lee Moffitt Cancer Center, Tampa, FL, USA * These authors have contributed equally to this work Correspondence to: Lili Yang, email: yanglili@tjmuch.com Pearlie K. Epling-Burnette, email: Pearlie.Burnette@moffitt.org Keywords: MDS, T-cells, telomerase, hTERT, hTERT alternative splice variants Received: July 27, 2016 Accepted: September 10, 2016 Published: September 19, 2016 ABSTRACT Telomere instability and telomerase reactivation are believed to play an important role in the development of myelodysplastic syndromes (MDS). Abnormal enzymatic activity of human telomerase reverse transcriptase (hTERT), and its alternative splice variants have been reported to account for deregulated telomerase function in many cancers. In this study, we aim to compare the differences in expression of hTERT and hTERT splice variants, as well as telomere length and telomerase activity in unstimulated T-cells between MDS subgroups and healthy controls. Telomere length in MDS cases was significantly shorter than controls (n = 20, p |
| Databáze: | OpenAIRE |
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