Enhanced Sympathetic Activity in Mice with Brown Adipose Tissue Transplantation (TransBATation)
| Autor: | Zheng Zhu, Elizabeth G. Spicer, Haifei Shi, Colleen M. Novak, Chaitanya K. Gavini, Ashley J. Goudjo-Ako |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic nervous system Calorie Sympathetic Nervous System Adipose Tissue White Experimental and Cognitive Psychology White adipose tissue Biology Diet High-Fat Article Body Temperature Behavioral Neuroscience Norepinephrine Mice Adipose Tissue Brown Internal medicine Brown adipose tissue medicine Animals Obesity Muscle Skeletal Cold-Shock Response Myocardium digestive oral and skin physiology Body Weight food and beverages nutritional and metabolic diseases Heart Thermogenin Cold shock response Transplantation Endocrinology medicine.anatomical_structure Liver Energy Intake Energy Metabolism hormones hormone substitutes and hormone antagonists medicine.drug |
| Popis: | Brown adipose tissue (BAT) burns calories to produce heat, and is thus relevant to energy balance. Interscapular BAT (IBAT) of donor mice was transplanted into recipient mice (transBATation). To test whether transBATation counteracts high-fat diet (HFD)-induced obesity, some sham-operated and recipient mice were fed a HFD (HFD-sham, HFD-trans) while others remained on a standard chow (chow-sham, chow-trans). HFD-trans mice had lower body weight and fat and greater energy expenditure, but similar caloric intake compared with HFD-sham mice. We hypothesized that HFD-trans mice had elevated sympathetic activity compared with HFD-sham mice, contributing to increased energy expenditure and fuel mobilization. This was supported by findings that HFD-trans mice had greater energy expenditure during a norepinephrine challenge test and higher core temperatures after cold exposure than did HFD-sham mice, implicating enhanced whole-body metabolic response and elevated sympathetic activity. Additionally, transBATation selectively increased sympathetic drive to some, but not all, white adipose tissue depots and skeletal muscles, as well as the endogenous IBAT, heart, and liver. Collectively, transBATation confers resistance to HFD-induced obesity via increase in whole-body sympathetic activity, and differential activation of sympathetic drive to some of the tissues involved in energy expenditure and fuel mobilization. |
| Databáze: | OpenAIRE |
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