Clinical features and prognostic factors of WHO II and III adult spinal meningiomas: analysis of 25 cases in a single center
| Autor: | Jingliang Ye, Guoguang Lv, Chun Luo, Junle Zhu, Ruizhang Han, Jun Qian |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research Prognostic variable medicine.medical_specialty Multivariate analysis Disease Single Center World Health Organization Meningioma 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine Meningeal Neoplasms Medicine Humans Survival rate Aged Neoplasm Staging Retrospective Studies business.industry Medical record Retrospective cohort study Middle Aged medicine.disease Prognosis Survival Analysis Surgery Treatment Outcome Neurology Oncology 030220 oncology & carcinogenesis Multivariate Analysis Female Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of neuro-oncology. 128(2) |
| ISSN: | 1573-7373 |
| Popis: | Spinal World Health Organization (WHO) II and III meningiomas are relatively rare, and often associated with great clinical aggressiveness and poor overall survival. There are controversies over factors affecting the prognosis of this disease. The aim of this retrospective study was to evaluate factors that may affect the therapeutic outcome and prognosis of adult high-grade spinal meningiomas by reviewing the medical records of 25 patients who were surgically treated in our hospital between 2001 and 2014. Univariate and multivariate analyses were performed to identify prognostic variables relative to patient and tumor characteristics, and treatment modalities. All 25 patients (14 men and 11 women; mean age 46.6 ± 16.1 years) underwent surgical resection. Local recurrence was occurred in 13 (52.0 %) patients, and 10 (40.0 %) patients died during the follow-up periods. The 5-year recurrence rate was 60.0 % and the 5-year survival rate was 68.0 %. The results of statistical analysis suggested that Simpson resection grade and the number of involved segments were prognostic factors related to progression-free survival and that sex, age, preoperative Frankel score, the number of involved segments and WHO grade were closely correlated with survival. Furthermore, we confirmed that the number of involved segments was the major independent factor affecting recurrence of patients with adult spinal high-grade meningiomas, and that sex, age and WHO grade were prognostic factors affecting survival but not recurrence. |
| Databáze: | OpenAIRE |
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