Antimicrobial Efficacy of a Historical High-Frequency Plasma Apparatus in Comparison With 2 Modern, Cold Atmospheric Pressure Plasma Devices
| Autor: | Sebastian von Podewils, Georg Daeschlein, Romy Spitzmueller, Matthias Napp, Steffen Emmert, Judith Napp, Andreas W. Arnold, Sebastian Scholz, Michael Jünger, Hermann Haase, Denis Gümbel |
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| Rok vydání: | 2015 |
| Předmět: |
010302 applied physics
Bacteria Plasma Gases business.industry Antimicrobial efficacy Biomedical Engineering Atmospheric-pressure plasma Equipment Design Dielectric barrier discharge Plasma Models Biological 01 natural sciences 010305 fluids & plasmas Anti-Infective Agents Biofilms 0103 physical sciences Medicine Surgery Plasma medicine business Electrodes Biomedical engineering |
| Zdroj: | Surgical Innovation. 22:394-400 |
| ISSN: | 1553-3514 1553-3506 |
| DOI: | 10.1177/1553350615573584 |
| Popis: | Background. Today, highly sophisticated devices deliver cold atmospheric pressure plasma (CAPP) with a multitude of bioactive properties, opening the window to a new medical field: plasma medicine. Different techniques to create the optimal plasma device for different medical indications are currently being explored. However, even a 100 years ago, CAPP was briefly used in the related form of high-frequency therapy. The objective of our study was to compare historic with modern techniques regarding antimicrobial efficacy. Methods. First, 26 different clinical isolates of relevant wound pathogens were treated in vitro with a historic violet wand (VW) and 2 modern plasma sources (kINPen 09 and dielectric barrier discharge [DBD]) and the obtained inhibition areas (IAs) were compared. Second, a biofilm model was used to compare biofilm inactivation by VW, DBD, ethanol, and polyhexanide treatment. Results. DBD with the largest electrode produced the largest IAs. VW showed results similar to 2 different modes of the kINPen 09. IAs of VW were enlargeable by attaching a larger electrode. Against biofilms, VW was less effective than DBD but more effective than ethanol 70% and polyhexanide. Conclusion. The proven antimicrobial efficacy of VW may encourage the development of new, potent plasma devices based on the very simple and inexpensive technique of the historic high-frequency apparatus. |
| Databáze: | OpenAIRE |
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