Vitamin D deficiency in type 1 narcolepsy: a reappraisal
| Autor: | Bertrand Carlander, Yves Dauvilliers, Régis Lopez, Barbara Crastes de Paulet, Sabine Scholz, Isabelle Jaussent, Lucie Barateau, Elisa Evangelista |
|---|---|
| Přispěvatelé: | Département de neurologie [Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Sleepiness Population Autoimmunity Disease Logistic regression vitamin D deficiency White People 03 medical and health sciences 0302 clinical medicine Sex Factors Internal medicine Vitamin D and neurology Medicine Humans Vitamin D education Narcolepsy 2. Zero hunger education.field_of_study business.industry Vaccination Confounding Age Factors General Medicine medicine.disease Vitamin D Deficiency 3. Good health 030104 developmental biology Endocrinology Case-Control Studies [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Seasons business Body mass index [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery Hypocretin/orexin Blood sampling |
| Zdroj: | Sleep Medicine Sleep Medicine, Elsevier, 2017, 29, pp.1-6. ⟨10.1016/j.sleep.2016.05.008⟩ |
| ISSN: | 1878-5506 1389-9457 |
| DOI: | 10.1016/j.sleep.2016.05.008⟩ |
| Popis: | International audience; OBJECTIVES:Narcolepsy type 1 (NT1) is considered to be an immune-mediated disease in which environmental factors, such as vitamin D, might play a major role. The association between NT1 and vitamin D deficiency has previously been reported. The aim of this case-control study was to reassess vitamin D levels in a large clinic-based adult and paediatric population of patients with NT1 by considering several potential confounding factors.METHODS:The serum level of 25-hydroxyvitamin D (25OHD) was measured in 174 Caucasian patients with NT1 and 174 controls. Demographic and clinical features, body mass index (BMI), Pandemrix® vaccination, age, and season at the time of blood sampling were recorded. Between-group comparisons were made using univariate and multivariate logistic regression analyses. When appropriate, interaction terms were tested using the Wald Chi-squared test.RESULTS:Age, BMI, and season of blood sampling were different between groups. Conversely, the 25OHD level and fraction of subjects with vitamin D deficiency (serum level |
| Databáze: | OpenAIRE |
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