Rheumatic Heart Disease: Pathogenesis and Vaccine
| Autor: | Edilberto Postol, William Ribeiro da Silva, Silvia Regina Cavani Jorge Santos, Luiza Guilherme, F Morais Ferreira, R. Alencar, Jorge Kalil, Karen Francine Köhler, S. Freschi de Barros |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Heart disease Streptococcus pyogenes Autoimmunity Disease medicine.disease_cause Biochemistry 03 medical and health sciences Chorea medicine Humans Molecular Biology Vaccines business.industry Molecular Mimicry Histocompatibility Antigens Class II Rheumatic Heart Disease Carditis Cell Biology General Medicine medicine.disease Molecular mimicry 030104 developmental biology Immunology Rheumatic fever Cytokines Polyarthritis medicine.symptom Rheumatic Fever business BRASILEIROS |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1875-5550 |
| Popis: | Rheumatic fever (RF) and rheumatic heart disease (RHD) follow untreated S. pyogenes throat infections in children who present susceptible genes that favor the development of autoimmune reactions. In this review, we focus on the genes that confer susceptibility and on the autoimmune reactions that occur due to molecular mimicry between human-tissue proteins and streptococcal M protein. Polyarthritis is the initial manifestation, which can evolve to carditis and severe valve damage; these culminate in rheumatic heart disease (RHD) or Sydenham's chorea, which affects the central nervous system. A perspective on vaccine development to prevent the disease is also discussed. |
| Databáze: | OpenAIRE |
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