Epstein-Barr Virus in Nasopharyngeal Carcinoma of Guatemalan and Brazilian Patients
| Autor: | Roman Carlos, Harim Tavares dos Santos, Albina Altemani, Alicia Rumayor Piña, Oslei Paes de Almeida |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Epstein-Barr Virus Infections Herpesvirus 4 Human Pathology medicine.medical_specialty Adolescent education Biology Adenoid medicine.disease_cause Virus Pathology and Forensic Medicine Young Adult 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases parasitic diseases otorhinolaryngologic diseases Carcinoma medicine Humans Aged Aged 80 and over Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms Middle Aged Guatemala medicine.disease Epstein–Barr virus Virology stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Female Surgery Anatomy Brazil |
| Zdroj: | International Journal of Surgical Pathology. 25:304-309 |
| ISSN: | 1940-2465 1066-8969 |
| Popis: | Background. Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV), particularly the undifferentiated nonkeratinizing subtype. Prevalence of EBV in NPC in countries such as Guatemala and Brazil has not been studied. Methods. We analyzed 19 cases of NPC, 11 from Guatemala and 8 from Brazil, for the presence of EBV by in situ hybridization and immunohistochemistry. Additionally, 19 hyperplastic adenoids from children were analyzed for EBV by in situ hybridization, 12 from Guatemala and 7 from Brazil. Results. All the NPC cases from Guatemala and 5 from Brazil were of the undifferentiated nonkeratinizing type. EBV-negative cases comprised 2 keratinizing NPC and 1 differentiated nonkeratinizing NPC. All undifferentiated nonkeratinizing NPC from both samples showed intense positivity for EBER, while LMP-1 only focally and scarcely expressed. EBER was positive in 75% and 43% of the adenoids from Guatemala and Brazil, respectively. Conclusions. All undifferentiated nonkeratinizing NPC irrespective of origin from Guatemala or Brazil were highly associated with EBV. |
| Databáze: | OpenAIRE |
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