PneumocystisColonization in Immunocompetent and Simian Immunodeficiency Virus-infected Cynomolgus Macaques
| Autor: | Alison Morris, Timothy W. Shipley, Karen A. Norris, Sangita Patil, Heather M. Kling |
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| Rok vydání: | 2009 |
| Předmět: |
Simian Acquired Immunodeficiency Syndrome
Pneumocystis carinii medicine.disease_cause Polymerase Chain Reaction Article law.invention Serology law medicine Animals Immunology and Allergy Pneumocystis jirovecii Polymerase chain reaction biology medicine.diagnostic_test Pneumocystis Pneumonia Pneumocystis Serine Endopeptidases Antibody titer Simian immunodeficiency virus biology.organism_classification Virology Macaca fascicularis Infectious Diseases Bronchoalveolar lavage Immunology biology.protein Antibody Immunocompetence |
| Zdroj: | Journal of Infectious Diseases. 199:89-96 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Pneumocystis (Pc) colonization is common among human immunodeficiency virus (HIV)-infected subjects, although the clinical consequences of Pc carriage are not fully understood. We examined the frequency of asymptomatic carriage in healthy and simian immunodeficiency virus (SIV)-infected cynomolgus macaques by use of polymerase chain reaction (PCR) and assessment of changes in the serologic response to a recombinant fragment of the Pc protein kexin (KEX1). Anti-KEX1 antibodies were detected in 95% of healthy monkeys. To create a model of natural transmission of Pc, SIV-infected monkeys were cohoused with macaques coinfected with SIV and Pc. Pc colonization occurred when the CD4(+) T cell count decreased to |
| Databáze: | OpenAIRE |
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