The regulation of food intake by the gut-brain axis: implications for obesity
| Autor: | Syed Sufyan Hussain, Stephen R. Bloom |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Leptin
Male medicine.medical_specialty Food intake Endocrinology Diabetes and Metabolism media_common.quotation_subject Peptide Hormones Gut–brain axis Hypothalamus Medicine (miscellaneous) 030209 endocrinology & metabolism Satiation Neuronal circuitry Energy homeostasis 03 medical and health sciences Eating 0302 clinical medicine Internal medicine medicine Homeostasis Humans Autonomic Pathways Obesity 030304 developmental biology media_common 2. Zero hunger 0303 health sciences Nutrition and Dietetics business.industry Appetite Regulation Appetite medicine.disease Gut hormones 3. Good health Gastrointestinal Tract Endocrinology Female business Neuroscience Signal Transduction |
| Zdroj: | International Journal of Obesity; Vol 37 |
| ISSN: | 1476-5497 |
| DOI: | 10.1038/ijo.2012.93 |
| Popis: | Our understanding of the regulation of appetite has improved considerably over the last few decades. Recent work, stimulated by efforts aimed at curbing the current obesity epidemic, has unravelled some of the complex pathways regulating energy homeostasis. Key factors to this progress have been the discovery of leptin and the neuronal circuitry involved in mediating its effects, as well as the identification of gut hormones that have important physiological roles relating to energy homeostasis. Despite these advances in research, there are currently no effective treatments for the growing problem of obesity. In this article, we summarise the regulatory pathways controlling appetite with a special focus on gut hormones. We detail how recent findings have contributed to our knowledge regarding the pathogenesis and treatment of common obesity. A number of barriers still need to be overcome to develop safe and effective anti-obesity treatments. We outline problems highlighted by historical failures and discuss the potential of augmenting natural satiety signals, such as gut hormones, to treat obesity. |
| Databáze: | OpenAIRE |
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