Inter-Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review
| Autor: | Edith Visser, Baukje de Roos, Johanna M. Geleijnse |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Gerontology Nutrition and Disease Alcohol Drinking biological responsiveness coffee Coffee consumption Health outcomes Coffee 03 medical and health sciences Gamma glutamyl transferase nutrigenomics Risk Factors Voeding en Ziekte Caffeine Neoplasms inter-individual variation Humans VLAG caffeine Supplementary data Polymorphism Genetic 030109 nutrition & dietetics Conflict of interest 030104 developmental biology Variation (linguistics) Cardiovascular Diseases Female Psychology Food Science Biotechnology |
| Zdroj: | Molecular Nutrition and Food Research 64 (2020) 7 Molecular Nutrition and Food Research, 64(7) |
| ISSN: | 1613-4125 |
| Popis: | Scope: Coffee is associated with a lower risk of cancer, cardiovascular disease, and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption are systematically evaluated. Methods and results: Embase and MEDLINE are searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies meet the inclusion criteria, which report variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. The qualitative analysis shows that sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit the majority of studies have insufficient statistical power to detect significant interaction between these factors and coffee consumption. Conclusion: Several genetic and non-genetic determinants of inter-individual variability in the responses to coffee and caffeine consumption are identified, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects. |
| Databáze: | OpenAIRE |
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