Biodegradable nanoparticles for the treatment of epilepsy: from current advances to future challenges
| Autor: | Antoni Camins, Lorena Bonilla, Maria Luisa García, Elena Sánchez-López, Miren Ettcheto, Gerard Esteruelas, Marta Espina, Eliana B. Souto, Amanda Cano |
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| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Drug
media_common.quotation_subject Context (language use) Disease Bioinformatics Polymeric nanoparticles Epilepsy Drug Delivery Systems medicine Humans Nanotechnology media_common Drug Carriers Science & Technology Nanopartícules business.industry Nanotecnologia Neurodegeneration Malalties neurodegeneratives Neurodegenerative diseases Neurodegenerative Diseases medicine.disease Epilèpsia Nanomedicine Neurology Drug delivery Lipid nanoparticles Nanoparticles Neurology (clinical) Nanocarriers business |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid based nanocarriers as novel tools for the management of epilepsy disorders. Amanda Cano acknowledges the support of the Spanish Ministry of Science, Innovation and Universities under the grant Juan de la Cierva (FJC2018-036012-I). Authors acknowledge the support of the Spanish Ministry of Economy and Ccompetitiveness under project SAF2017-84283-R; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED, CB06/05/0024) and Portuguese Science and Technology Foundation (FCT) for the strategic fund (UIDB/04469/2020). info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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