Taste perception and lifestyle: insights from phenotype and genome data among Africans and Asians
| Autor: | Mattias Jakobsson, Agnès E. Sjöstrand, Anna Nikolaeva, Tatyana Hegay, Per Sjödin, Farhad Shayimkulov, Michael G. B. Blum, Evelyne Heyer |
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| Přispěvatelé: | Éco-Anthropologie (EAE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
MESH: Continental Population Groups Taste Adolescent Genotype media_common.quotation_subject Population [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology Black People Biology Article MESH: Anthropology Young Adult 03 medical and health sciences Asian People Perception Genetic variation Genetics Humans MESH: Racism education Life Style Genetics (clinical) media_common Genetic association 2. Zero hunger 0303 health sciences education.field_of_study Genome MESH: Humans 030305 genetics & heredity Taste Perception Middle Aged Tongue morphogenesis MESH: France Phenotype Evolutionary biology MESH: History 19th Century MESH: History 20th Century MESH: History 21st Century Diversity (politics) |
| Zdroj: | European Journal of Human Genetics European Journal of Human Genetics, Nature Publishing Group, 2020, 95, pp.307-310. ⟨10.1038/s41431-020-00736-2⟩ Eur J Hum Genet |
| ISSN: | 1018-4813 1476-5438 |
| DOI: | 10.1038/s41431-020-00736-2⟩ |
| Popis: | International audience; Taste is essential for the interaction of animals with their food and has co-evolved with diet. Humans have peopled a large range of environments and present a wide range of diets, but little is known about the diversity and evolution of human taste perception. We measured taste recognition thresholds across populations differing in lifestyles (hunter gatherers and farmers from Central Africa, nomad herders, and farmers from Central Asia). We also generated genome-wide genotype data and performed association studies and selection scans in order to link the phenotypic variation in taste sensitivity with genetic variation. We found that hunter gatherers have lower overall sensitivity as well as lower sensitivity to quinine and fructose than their farming neighbors. In parallel, there is strong population divergence in genes associated with tongue morphogenesis and genes involved in the transduction pathway of taste signals in the African populations. We find signals of recent selection in bitter taste-receptor genes for all four populations. Enrichment analysis on association scans for the various tastes confirmed already documented associations and revealed novel GO terms that are good candidates for being involved in taste perception. Our framework permitted us to gain insight into the genetic basis of taste sensitivity variation across populations and lifestyles. |
| Databáze: | OpenAIRE |
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