Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: A proof of concept study

Autor:	Nicolas Vodovar, Andreia de Sousa Jorge, Magali Genest, Karine Santos, Mandy Kästorf, Andreas Bergmann, Alexandre Mebazaa, Feriel Azibani, Benjamin Deniau, Prabakar Vaittinada Ayar, Malha Sadoune, Alice Blet, Jane Lise Samuel
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male Cardiac output Physiology Hemodynamics Blood Pressure 030204 cardiovascular system & hematology Cardiovascular Physiology Vascular Medicine 0302 clinical medicine Blood plasma Medicine and Health Sciences Enzyme Inhibitors Mammals Multidisciplinary Eukaryota Heart Stroke volume Hematology Animal Models Body Fluids Blood Experimental Organism Systems Vertebrates Medicine Anatomy Research Article Cardiac function curve medicine.medical_specialty Systole Science Research and Analysis Methods Rodents Proof of Concept Study Dipeptidyl peptidase Blood Plasma Sepsis 03 medical and health sciences Signs and Symptoms Model Organisms Internal medicine medicine Animals Rats Wistar Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Septic shock business.industry Organisms Biology and Life Sciences 030208 emergency & critical care medicine Cell Biology medicine.disease Rats Oxidative Stress Disease Models Animal Endocrinology Amniotes Cardiovascular Anatomy Animal Studies Clinical Medicine business Zoology
Zdroj:	PLoS ONE PLoS ONE, Vol 15, Iss 8, p e0238039 (2020)
ISSN:	1932-6203
Popis:	Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) is elevated in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in non-survivor septic shock patients. The aim of this study was to evaluate the benefits of inhibiting cDPP3 by a specific antibody, Procizumab (PCZ), on cardiac function in an experimental model of sepsis, the caecal ligature and puncture (CLP) model. Rats were monitored by invasive blood pressure and echocardiography. Results are presented as mean ± SD, with p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4940458224e8f91f2e88a0f5478c76 http://europepmc.org/articles/PMC7451654 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.