Effect of Physical Exercise on the Content of 8-Hydroxydeoxyguanosine in Nuclear DNA Prepared from Human Lymphocytes
| Autor: | Tamotsu Inoue, Toshikazu Okochi, Zhouseng Mu, Kazuhide Sumikawa, Kozaburo Adachi |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Purine Cancer Research medicine.medical_specialty DNA damage Physical exercise Urine 8‐Hydroxydeoxyguanosine Xanthine Article Running chemistry.chemical_compound Internal medicine medicine Humans Lymphocytes Exercise Swimming Hypoxanthine Deoxyguanosine 8-Hydroxy-2'-deoxyguanosine DNA Uric Acid Endocrinology Hematocrit Oncology chemistry Biochemistry 8-Hydroxy-2'-Deoxyguanosine Oxidative DNA damage Creatinine Hypoxanthines Xanthines Uric acid Oxidation-Reduction DNA Damage |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.1993.tb02035.x |
| Popis: | Effects of exercise on the formation of 8‐hydroxydeoxyguanosine (8‐OH‐dG), a biomarker of oxidative DNA damage, and other purine metabolites such as hypoxanthine, xanthine and uric acid were examined. Venous blood and urine were collected from swimmers and distance runners before and after the usual training. The amount of 8‐OH‐dG obtained from nuclear DNA of lymphocytes decreased remarkably after intermittent swimming. The amount of nuclear 8‐OH‐dG also declined after distance running, but this difference is statistically not significant. After each exercise, plasma concentrations of hypoxanthine, xanthine and uric acid rose significantly. Urinary excretion of hypoxanthine increased, and xanthine and uric acid decreased after exercise. The 8‐OH‐dG‐to‐creatinine ratio in urine increased slightly after swimming or running. It is supposed that the repair of oxidative DNA damage is augmented by exercise. As far as we know, this is the first report concerning the effect of exercise on oxidative damage in nuclear DNA. |
| Databáze: | OpenAIRE |
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