Tough and biodegradable polyurethane-curcumin composited hydrogel with antioxidant, antibacterial and antitumor properties
| Autor: | Jiehua Li, Hong Tan, Bohong Du, Jianghui Hong, Hang Yin, Yuanyuan He, Kecen Xiao, Feng Luo, Yuan Feng, Dan Lu, Zhen Li, Qiang Fu |
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| Rok vydání: | 2021 |
| Předmět: |
Curcumin
Antioxidant Materials science medicine.medical_treatment Polyurethanes Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Antioxidants Biomaterials chemistry.chemical_compound Copolymer medicine Polyurethane technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology Anti-Bacterial Agents 0104 chemical sciences Membrane chemistry Chemical engineering Mechanics of Materials Self-healing hydrogels Surface modification Degradation (geology) 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 121:111820 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2020.111820 |
| Popis: | The functionalization of tough and biodegradable hydrogels is an important way to broaden their applications in biomedical field. However, most of the hydrophobic functional drugs are difficult to incorporate with the hydrogels. In this work, curcumin (Cur), a hydrophobic functional drug, was chosen to composite with polyurethane (PU) to obtain PU-Cur hydrogels by a direct and simple in-situ copolymerization. The incorporation of curcumin in PU hydrogel increases the crosslink but reduces the hydrophilicity and degradation rate of PU-Cur hydrogels. Thus, it can increase the mechanical strength to a maximum of 6.4±0.8 MPa and initial modulus to a maximum of 3.0±0.4 MPa. More importantly, curcumin incorporated in PU networks is not deactivated. The degradation products of PU-Curs at relatively low concentrations (2.5 mg/mL) can scavenge free radicals very efficiently (maximum over 90%), which exhibits strong antioxidant properties to improve wound healing. Moreover, based on the photochemical activity of curcumin, notable inhibition effects of the degradation products of PU-Curs against bacteria (maximum over 80%) and cancer cells are demonstrated with blue light treatment as a photodynamic therapy (PDT). Therefore, the beneficial effects of curcumin are retained in PU-Cur hydrogels, suggesting potential use as wound dressings or tumor isolation membranes. This work proposes a promising strategy to combine hydrophobic functional drugs with hydrophilic hydrogels for applications in a wide range of biomaterials. |
| Databáze: | OpenAIRE |
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