Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei
| Autor: | Craig A. Stockmeier, Katalin Szebeni, Emily Nail, Laurel Johnson, Beata Karolewicz, He Zhu, Gregory A. Ordway, Violetta Klimek |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Monoamine Oxidase Inhibitors Monoamine oxidase Tritium Amygdala Article Radioligand Assay chemistry.chemical_compound Dopamine Internal medicine medicine Humans Picolinic Acids Neurotransmitter Monoamine Oxidase Molecular Biology Aged Retrospective Studies Dopamine transporter Depressive Disorder Major biology General Neuroscience Smoking Dopaminergic Middle Aged Endocrinology medicine.anatomical_structure chemistry biology.protein Autoradiography Female Lazabemide Neurology (clinical) Monoamine oxidase B Psychology Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1043:57-64 |
| ISSN: | 0006-8993 |
| Popis: | Altered concentrations of dopamine transporter and D2/D3 receptors have been observed in the amygdaloid complex of subjects with major depression. These findings are suggestive of neurochemical abnormalities in the limbic dopamine system in depression. Monoamine oxidase-B (MAO-B) is a key enzyme in the catabolism of biogenic amines, including dopamine, and alterations in this enzyme may underlie dopaminergic abnormalities associated with depression. The specific binding of [(3)H]lazabemide to MAO-B was measured in the right amygdaloid complex of 15 major depressive subjects and 16 psychiatrically normal controls. Subjects of the two study groups were matched as close as possible for age, sex, and postmortem interval. Examination of the regional distribution of MAO-B revealed lower [(3)H]lazabemide binding to MAO-B in the lateral and basal nuclei of the amygdala and higher binding in the medial nucleus. A modest elevation in binding to MAO-B observed in all amygdaloid nuclei in major depressive subjects as compared to control subjects failed to reach statistical significance. A significant decrease in binding to MAO-B was observed when cigarette smokers were compared to nonsmoking subjects. The amount of MAO-B binding positively correlated with the age of subjects in all nuclei investigated. A decreased amount of MAO-B in smokers further validates the pharmacological effect of tobacco smoke on this enzyme. |
| Databáze: | OpenAIRE |
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