Ploidy and S-phase fraction are correlated with lymphovascular space invasion that is predictive of outcomes in endometrial cancer
| Autor: | Byoung-Gie Kim, Sang Yong Song, Chel Hun Choi, Chang Ohk Sung, Tae-Joong Kim, Duk-Soo Bae, Taejong Song, Jeong-Won Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis medicine.drug_class Aneuploidy Disease-Free Survival S Phase Surgical oncology Internal medicine Progesterone receptor Odds Ratio Humans Medicine Pathological Aged Lymphatic Vessels Ploidies business.industry Endometrial cancer Hematology General Medicine Middle Aged Prognosis medicine.disease Lymphovascular Endometrial Neoplasms Estrogen Lymphatic Metastasis Female Surgery business |
| Zdroj: | International Journal of Clinical Oncology. 17:590-597 |
| ISSN: | 1437-7772 1341-9625 |
| Popis: | Pathological detection of lymphovascular space invasion (LVSI) is a useful prognostic marker for patients with endometrial cancer. However, LVSI is criticized for its subjectivity and poor reproducibility. To improve the outcomes of patients with endometrial cancer, we evaluated objective parameters associated with LVSI to generate more accurate LVSI assessments and to identify patients with high-risk disease. We reviewed the medical records of 137 patients with endometrial cancer. Flow cytometry was used to determine DNA ploidy and S-phase fraction. Estrogen and progesterone receptor (ER and PR) levels and p53 and k-ras mutational status were tested. LVSI was found in 36 patients (26.3%). Patients with LVSI had significantly decreased recurrence-free survival and overall survival compared to those without LVSI. Aneuploid tumors were significantly more frequent in LVSI-positive patients compared with LVSI-negative patients (odds ratio = 5.208, P |
| Databáze: | OpenAIRE |
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