Cis-glyco-fused benzopyran compounds as new amyloid β peptide ligands

Autor:	Cristina Airoldi, Laura Colombo, Francisco Cardona, Mario Salmona, Francesco Nicotra, Erika Sironi, Barbara La Ferla, Artur M. S. Silva
Přispěvatelé:	Airoldi, C, Cardona, F, Sironi, E, Colombo, L, Salmona, M, Silva, A, Nicotra, F, LA FERLA, B
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	Stereochemistry Ligands 010402 general chemistry 01 natural sciences Molecular mechanics Catalysis Beta amyloid peptides glycofused compounds Abeta ligands chemistry.chemical_compound Molecular dynamics CHIM/06 - CHIMICA ORGANICA Materials Chemistry Benzopyrans Amyloid beta-Peptides 010405 organic chemistry Metals and Alloys Stereoisomerism General Chemistry Combinatorial chemistry Amyloid β peptide 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Benzopyran chemistry Ceramics and Composites Protein Binding
Popis:	A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa42a8312ccfebb083660444824c82fe http://hdl.handle.net/10281/24573 Zobrazit plný text záznamu