Prophylactic administration of amoxicillin and clavulanic acid in pregnant women with premature rupture of the membranes
| Autor: | P. Tampakoudis, J. Kalachanis, S. Mantalenakis, A. Andreu, G. Grimbizis |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Fetal Membranes Premature Rupture Gestational Age Chorioamnionitis Umbilical cord Clavulanic Acids Pregnancy medicine Humans Pharmacology (medical) Prospective Studies Enzyme Inhibitors Beta-Lactamase Inhibitors Clavulanic Acid Antibacterial agent Pharmacology Fetus Obstetrics business.industry Gestational age Amoxicillin Bacterial Infections medicine.disease Surgery Infectious Diseases medicine.anatomical_structure Oncology Evaluation Studies as Topic Drug Therapy Combination Female business beta-Lactamase Inhibitors medicine.drug Follow-Up Studies |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 8(4) |
| ISSN: | 1120-009X |
| Popis: | Seventy-five pregnant women (mean gestational age 32.26 weeks, range 20-36 weeks) with premature rupture of the membranes (PROM) were admitted in our department during 1989 and the first 6 months of 1990. Amoxicillin and clavulanic acid was initially administered at a dose of 1.2 g i.v. every 8 hours for 3-4 days and was followed by oral administration of 625 mg every 8 hours until labor. Sixty-one patients (mean gestational age 32.6 +/- 2.3 weeks, range 26-36 weeks) achieved an uncomplicated course of their pregnancies with a mean time of 11.4 +/- 5.7 days (range 3-27 days), from rupture to delivery. Fourteen women (mean gestational age 30.8 +/- 5 weeks, range 20-36 weeks) developed chorioamnionitis 3.5 +/- 0.9 days (range 1.4-5.6 days) after the rupture with several degrees of leukocyte infiltration of the membranes, placenta and the umbilical cord. Five women (mean gestational age 23.8 +/- 2.3 weeks, range 20-26 weeks) had complications resulting in fetal/infant death, three of them because of fetal sepsis (Escherichia coli, Pseudomonas aeroginosa, Staphylococcus aureus). The newborns were followed up 6 months from delivery and had no signs of drug influence. Few side effects were observed with the chief complaints involving the gastrointestinal tract (4%). No one discontinued the drug. It seems therefore, that the prophylactic administration of amoxicillin and cluvalanic acid in women with PROM is associated with a significant prolongation of pregnancy and with a reduction in the incidence of fetal/maternal infections. |
| Databáze: | OpenAIRE |
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