Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice
| Autor: | Haim Einat, Shlomit Flaisher-Grinberg, Nirit Z. Kara |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Ampakine Bipolar Disorder medicine.drug_class CX717 AMPA receptor Motor Activity Work related Mice chemistry.chemical_compound Antimanic Agents medicine Animals Receptors AMPA Bipolar disorder Amphetamine Swimming Pharmacology Behavior Animal Dose-Response Relationship Drug Isoxazoles General Medicine medicine.disease Aggression Mood disorders chemistry Central Nervous System Stimulants medicine.symptom Psychology Neuroscience Mania medicine.drug |
| Zdroj: | Pharmacological Reports. 67:928-933 |
| ISSN: | 1734-1140 |
| Popis: | Background AMPA receptors are highly expressed throughout the central nervous system and are suggested to be involved in mood regulation. Studies found changes in glutamate, its metabolites and receptors in patients with bipolar disorder (BPD) or major depression (MD) and in animal models of stress. Additional data suggest that the glutamatergic system and AMPA receptors specifically, have an important role in modulating the therapeutic effects of mood stabilizers. Further research on the role of AMPA receptors in mood regulation can be done using AMPAkines, positive modulators of AMPA receptors. AMPAkines have been studied for cognitive enhancement in neurodegenerative disorders and some were also examined in preclinical studies of mood disorders. In that context, the present study was designed to test the effects of the AMPAkine CX717 in a strain specific battery of tests for mania-like behaviors. Methods Black Swiss male mice were sub-chronically treated with 5 different doses of CX717 or vehicle and tested in a battery of behavioral tests including spontaneous activity, sweet solution preference, resident-intruder, forced swim and amphetamine-induced hyperactivity. Results Data show that CX717 doses of 30 mg/kg and above, but not lower, reduce activity levels. Moreover, 45 mg/kg and above reduce interactions in the resident-intruder test and ameliorate amphetamine-induced hyperactivity. Conclusions The results therefore show a partial effect of CX717 on manic-like behavior, somewhat similar to previously demonstrated effects of atypical antipsychotic drugs in this strain. It is therefore suggested that further work related to AMPAkines in the treatment of affective disorders might be warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink