A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-Containing Scaffolds

Autor:	Nicolas Duchemin, Roberto Buccafusca, Stellios Arseniyadis, Marc Daumas, Vincent Ferey
Rok vydání:	2019
Předmět:	General method 010405 organic chemistry Chemistry Organic Chemistry Protonation 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry High yielding 0104 chemical sciences Electrophile Krapcho decarboxylation Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 21:8205-8210
ISSN:	1523-7052 1523-7060
Popis:	Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3f5c36a991a3df7ebaaba6b350f085 https://doi.org/10.1021/acs.orglett.9b02887 Zobrazit plný text záznamu