The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
| Autor: | Mostafa Behjati-Ardakani, Mojtaba Jaafarinia, Amin Safari-Arababadi, Seyed Mehdi Kalantar |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:R5-920 JAG1 Heart disease Heart development business.industry GATA4 General Medicine 030204 cardiovascular system & hematology Gene mutation medicine.disease Bioinformatics Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Genetic marker Tetralogy of Fallot Medicine lcsh:Medicine (General) business Congenital heart disease |
| Zdroj: | International Journal of Basic Science in Medicine, Vol 4, Iss 2, Pp 45-50 (2019) |
| ISSN: | 2476-664X |
| DOI: | 10.15171/ijbsm.2019.10 |
| Popis: | Congenital heart disease (CHD) is considered as an important and developing area in the medical community. Since these patients can reach maturity and have children, the role of genetic determinants in increasing risk of CHD is extremely evident among children of these patients. Because genetic studies related to CHD are increasing, and each day the role of new genetic markers is more and more clarified, this review re-examined the effects of gene mutations in the pathogenesis of tetralogy of Fallot (TOF) as an important pathological model among other CHDs. Due to the complexity of heart development, it is not astonishing that numerous signaling pathways and transcription factors, and many genes are involved in pathogenesis of TOF. This review focuses on the jag1, nkx2.5, gata4, zfpm2/fog2 and cited2 genes previously reported to be involved in TOF. |
| Databáze: | OpenAIRE |
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