Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population
| Autor: | Barbara Lucignano, Valeria Cento, Marilena Agosta, Federico Ambrogi, Sami Albitar-Nehme, Livia Mancinelli, Giordana Mattana, Manuela Onori, Federica Galaverna, Luca Di Chiara, Tiziana Fragasso, Roberto Bianchi, Francesca Tortora, Cinzia Auriti, Andrea Dotta, Corrado Cecchetti, Salvatore Perdichizzi, Massimiliano Raponi, Andrea Onetti Muda, Silvia Nerini Molteni, Alberto Villani, Franco Locatelli, Carlo Federico Perno, Paola Bernaschi |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Technology Magnetic Resonance Spectroscopy Bacteria bloodstream infections T2 magnetic resonance Infant Newborn Bacteriology Settore MED/38 Mycoses Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Blood Culture Sepsis molecular diagnosis Humans T2 panels Child pediatric population |
| Zdroj: | J Clin Microbiol |
| Popis: | Children are prone to bloodstream infections (BSIs), the rapid and accurate diagnosis of which is an unmet clinical need. The T2MR technology is a direct molecular assay for identification of BSI pathogens, which can help to overcome the limits of blood culture (BC) such as diagnostic accuracy, blood volumes required, and turnaround time. We analyzed results obtained with the T2Bacteria (648) and T2Candida (106) panels in pediatric patients of the Bambino Gesù Children’s Hospital between May 2018 and September 2020 in order to evaluate the performance of the T2Dx instrument with respect to BC. T2Bacteria and T2Candida panels showed 84.2% and 100% sensitivity with 85.9% and 94.1% specificity, respectively. The sensitivity and specificity of the T2Bacteria panel increased to 94.9% and 98.7%, respectively, when BC was negative but other laboratory data supported the molecular result. T2Bacteria sensitivity was 100% with blood volumes |
| Databáze: | OpenAIRE |
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