Extended criteria for liver transplantation in hepatocellular carcinoma : a retrospective, multicentric validation study in Belgium

Autor: Jacques Pirenne, Helena Degroote, Peter Michielsen, Christophe Moreno, V. Lucidi, Dirk Ysebaert, Chris Verslype, Samuele Iesari, Hans Van Vlierberghe, Jonas Schreiber, Jeroen Dekervel, Roberto Troisi, Jean Delwaide, Jan Lerut, Be-LIAC, Eduard Callebout, Olivier Detry
Přispěvatelé: Be-LIAC, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Carcinoma
Hepatocellular
Hepatocellular carcinoma
medicine.medical_treatment
030230 surgery
Liver transplantation
Milan criteria
Extended criteria
Gastroenterology
Organ transplantation
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Hepatitis B
Chronic
Belgium
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Humans
Asan criteria
Liver Diseases
Alcoholic
Metroticket 2.0 model
Aged
Retrospective Studies
business.industry
Patient Selection
Liver Neoplasms
Cancer
Hepatitis C
Chronic
Middle Aged
medicine.disease
Liver Transplantation
Extended transplant criteria
Survival Rate
Oncology
Up-to-7 criteria
030211 gastroenterology & hepatology
Surgery
Female
alpha-Fetoproteins
Human medicine
business
Alpha-fetoprotein
Alpha-foetoprotein
Zdroj: Surgical oncology
Surgical Oncology, Vol. 33, p. 231-238 (2020)
ISSN: 0960-7404
Popis: Background Recent studies indicate that a group of patients with cirrhosis receiving a liver transplantation for hepatocellular cancer (HCC) beyond the Milan Criteria (MC) can achieve a similar outcome compared to patients within these criteria. This study aims to investigate the value of the Asan critera (AC), up-to-7 criteria (UT7), French alpha-foetoprotein (AFP) model and Metroticket 2.0 (MT2.0) model compared to the MC. Methods 526 patients transplanted for non-metastatic HCC were analyzed. Patient groups within and beyond MC and extended criteria were determined according to radiological assessment and AFP value at listing. Results Overall survival (OS) and recurrence (RR) rates were similar between patients within MC and all extended criteria. Five-year OS within MC was 71.3% compared to 70.9% for AC, 71.4% for UT7, 69.7% for AFP-model and 71.0% for MT2.0 criteria. Five-year RR within MC was 12.3% compared to 13.5% for AC, 13.0% for UT7, 14.3% for AFP-model and 13.2% for MT2.0 criteria. Patients beyond MC but within the extended criteria had tendency towards higher recurrence. Conclusions All validated extended criteria (AC, UT7, AFP-model and MT2.0) could be proposed as alternatives to the MC with similar outcome. Prospective data are awaited to assess recurrence beyond MC.
Databáze: OpenAIRE
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