Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study
| Autor: | Atsunori Oga, Shin-ichiro Okuda, Fumio Iwasaki, Hitoshi Morioka, Tomoko Furuya, Yasuyo Chochi, Kohsuke Sasaki, Fujimi Fukuma, Shigeto Kawauchi |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Ovariectomy Cell Synaptophysin Mitosis Carcinoid Tumor Cervix Uteri Neuroendocrine tumors Biology Hysterectomy Pathology and Forensic Medicine Diagnosis Differential medicine Chromogranins Humans In Situ Hybridization Chromosome Aberrations Vaginal Smears Histocytochemistry Cytogenetics Chromosome Anatomical pathology DNA Neoplasm medicine.disease Immunohistochemistry Carcinoma Neuroendocrine medicine.anatomical_structure Phosphopyruvate Hydratase Cytogenetic Analysis Mitotic Figure Carcinoma Large Cell Chromogranin A Female Chromosomes Human Pair 3 Comparative genomic hybridization |
| Zdroj: | Human pathology. 36(10) |
| ISSN: | 0046-8177 |
| Popis: | Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a newly introduced category of the revised World Health Organization classification. We reported a case of cervical LCNEC with cytogenetic analysis by comparative genomic hybridization (CGH). The cervical tumor showed moderately increased mitotic activity (8-14 mitotic figures per 10 high-power fields) and focal necrosis, which made it problematic to differentiate from atypical carcinoid. CGH analysis failed to detect chromosome 11q loss that has been reported to be characteristic of pulmonary atypical carcinoids. Furthermore, chromosome 3q amplification, which has been detected frequently in pulmonary small cell carcinomas and LCNECs but not in pulmonary typical and atypical carcinoids, was the most remarkable chromosomal aberration. Although CGH reports are extremely rare in neuroendocrine tumors of the uterine cervix, specific chromosomal aberrations may be useful in their distinction. |
| Databáze: | OpenAIRE |
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