PCB-126 effects on aryl hydrocarbon receptor, ubiquitin and p53 expression levels in a fish product (Sparus aurata L.)
| Autor: | Margherita Calò, Nicola Cicero, Alessandra Bitto, Teresa Gervasi, Luca Campone, Domenica Altavilla, Filippo Giarratana, Patrizia Licata, Patrizia Lo Cascio |
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| Přispěvatelé: | Calo, M, Bitto, A, Lo Cascio, P, Giarratana, F, Altavilla, D, Gervasi, T, Campone, L, Cicero, N, Licata, P |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fish Proteins medicine.medical_specialty Plant Science 01 natural sciences Biochemistry Analytical Chemistry law.invention 03 medical and health sciences Ubiquitin law Internal medicine Fish Products medicine Animals aryl hydrocarbon Receptor P53 expression PCB-126 aryl hydrocarbon aurata L. tumour suppressor p53 biology Organic Chemistry Ubiquitination Aryl hydrocarbon receptor Polychlorinated Biphenyls Sea Bream 0104 chemical sciences Cancer treatment 010404 medicinal & biomolecular chemistry tumour suppressor p53 030104 developmental biology Endocrinology Liver Receptors Aryl Hydrocarbon biology.protein Fish Suppressor aurataL Tumor Suppressor Protein p53 PCB-126 |
| Zdroj: | Natural product research. 32(10) |
| ISSN: | 1478-6427 |
| Popis: | The aim of the present study is to determine if Ahr ligands as PCB-126, a dioxin-like, might contribute to inhibition of the tumour suppressor p53 by promoting its degradation through proteasome-ubiquitin system (UPS). The findings show, in the presence of PCB-126, a significant increase in p53 immunoreactivity in fish compared to the control. Subsequently, there is a decrease in p53 immunoreactivity at 24h which is maintained even at 72h. There is also a slight decrease in ubiquitin immunoreactivity to 12h compared to the control and a marked decrease to 24 and 72h. It’s very important to underline as in this study we demonstrate a marked decrease in ubiquitin and p53 immunoreactivity at 24 and 72h. Our result emphasise the need to deeply the role of this receptor in UPS regulation as potential therapeutic target for cancer treatment |
| Databáze: | OpenAIRE |
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