Immunohistochemical study of tumor cell-associated plasminogen activators and plasminogen activator inhibitors in lung carcinomas
| Autor: | Christiane Marty-Double, Pierre Balmes, Jean-Christophe Gris, Jean-François Schved, Jean-Marc Mauboussin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Cytoplasm Lung Neoplasms Adenocarcinoma Critical Care and Intensive Care Medicine Small-cell carcinoma Epithelium Carcinoma Non-Small-Cell Lung Biopsy Plasminogen Activator Inhibitor 1 medicine Plasminogen Activator Inhibitor 2 Humans Neoplasm Invasiveness Carcinoma Small Cell Lung Metaplasia medicine.diagnostic_test Staining and Labeling business.industry Carcinoma medicine.disease Immunohistochemistry Urokinase-Type Plasminogen Activator Staining medicine.anatomical_structure Tissue Plasminogen Activator Carcinoma Squamous Cell Cardiology and Cardiovascular Medicine business Plasminogen activator Immunostaining |
| Zdroj: | Chest. 104(1) |
| ISSN: | 0012-3692 |
| Popis: | Study objective To compare the expression of plasminogen activators (PA) and plasminogen activator inhibitors (PAI) in normal lung mucosa and lung carcinomas. Design Immunohistochemical localization of urokinase-type PA (uPA), tissue-type PA (tPA), type 1 PAI (PAI-1), and type 2 PAI (PAI-2) in four normal lung biopsy specimens and in four adenocarcinomas (AC), four squamous carcinomas (SC), two large-cell carcinomas (LCC), and ten small-cell carcinomas (SCC) biopsy specimens. Qualitative immunostaining scoring system. Results tPA and uPA immunostaining scores from all specimens were statistically similar. The cellular staining for uPA and tPA was generally constant (normal epithelial layers, AC cells, SC cells) except for LCC cells (inconstant uPA staining, p −3 ). Both PAIs were detected in cells of the normal epithelial layer. The four carcinoma cell types stained for PAI in a statistically different pattern (p −3 ). Cells of the peripheral cords of SCC were inconstantly PAI-1 and PAI-2 positive (p −3 ). LCC were PAI-2 negative and inconstantly stained for PAI-1. SCC cells were PAI-1 and PAI-2 negative. Conclusion Lung carcinomas of worst clinical prognosis no longer express PAI reactivity. The imbalance of the plasminogen activation pathway may favor the spreading of the more invasive histologic types of bronchogenic carcinomas. |
| Databáze: | OpenAIRE |
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