The IgE-binding self-antigens tubulin-α and HLA-DR-α are overexpressed in lesional skin of atopic eczema patients
| Autor: | Annika Scheynius, Sabine Zeller, Claudio Rhyner, Reto Crameri, Catharina Johansson |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
integumentary system biology business.industry Inflammation 610 Medicine & health Disease Immunoglobulin E Dermatology body regions Pathogenesis Immune system Downregulation and upregulation 10183 Swiss Institute of Allergy and Asthma Research Immunology biology.protein HLA-DR Medicine Immunohistochemistry medicine.symptom business |
| DOI: | 10.5167/uzh-60559 |
| Popis: | Background: Atopic eczema is the most common chronic, relapsing, inflammatory skin disorder with an atopic background. Previous studies have shown that IgE-mediated reactivity to self-antigens plays a role in the pathogenesis of the disease. However, the expression of self-antigens associated with atopic eczema in the lesional skin is poorly investigated.Aim of the study: This study was aimed to show that IgE-binding self antigens are over-expressed in atopic eczema lesions. Methods: Tubulin-α and HLA-DR-α, two recently described self-antigens, were stained by immunohistochemistry in skin specimens from chronic and acute atopic eczema lesions, unaffected skin from the same patients or skin from healthy controls.Results: The expression of tubulin-α and HLA-DR-α is up-regulated in atopic eczema lesions compared to nonlesional or healthy skin and correlates with the number of infiltrating immune cells and the degree of inflammation.Conclusion: Upregulation of IgE-binding self-antigens in lesional skin of atopic eczema patients might further promote the existing inflammation and induce exacerbations of the disease in the absence of exposure to environmental allergens. |
| Databáze: | OpenAIRE |
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