Parathyroid Hormone-Related Protein Inhibition Blocks Triple-Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal
Autor: | Mahvash Zakikhani, XiaoRui Luan, Catalin Mihalcioiu, Richard Kremer, Jiarong Li, Karine Sellin, Yubo Guo, Anne Camirand |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | JBMR plus. 6(6) |
ISSN: | 2473-4039 |
Popis: | Parathyroid hormone-related protein (PTHrP) plays a major role in skeletal metastasis but its action mechanism has not been fully defined. We previously demonstrated the crucial importance of PTHrP in promoting mammary tumor initiation, growth, and metastasis in a mouse model with a mammary epithelium-targeted |
Databáze: | OpenAIRE |
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