Parathyroid Hormone-Related Protein Inhibition Blocks Triple-Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal

Autor: Mahvash Zakikhani, XiaoRui Luan, Catalin Mihalcioiu, Richard Kremer, Jiarong Li, Karine Sellin, Yubo Guo, Anne Camirand
Rok vydání: 2021
Předmět:
Zdroj: JBMR plus. 6(6)
ISSN: 2473-4039
Popis: Parathyroid hormone-related protein (PTHrP) plays a major role in skeletal metastasis but its action mechanism has not been fully defined. We previously demonstrated the crucial importance of PTHrP in promoting mammary tumor initiation, growth, and metastasis in a mouse model with a mammary epithelium-targeted
Databáze: OpenAIRE
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