Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula
| Autor: | Adolfo Renzi, D. Mascagni, L. Del Re, R. Nudo, C. Bottini, G. Milito, Francesco Gabrielli, Lorenzo Ripamonti, Matteo Maternini, Angelo Guttadauro, Angelo Stuto |
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| Přispěvatelé: | Maternini, M, Guttadauro, A, Mascagni, D, Milito, G, Stuto, A, Renzi, A, Ripamonti, L, Bottini, C, Nudo, R, Del Re, L, Gabrielli, F |
| Rok vydání: | 2019 |
| Předmět: |
Anal fistula
EQUINE COLLAGEN medicine.medical_specialty Fistula medicine.medical_treatment lcsh:Surgery Non cutting technique Anal Canal Complex ano-rectal fistula 03 medical and health sciences 0302 clinical medicine Suture (anatomy) Recurrence Mini-invasive treatment Medicine Animals In patient Horses Prospective Studies Rectal fistula Anus Diseases Debridement business.industry complex ano-rectal fistula mini-invasive treatment non cutting technique animals anus diseases collagen fistula horses organ sparing treatments prospective studies rectal diseases recurrence treatment outcome anal canal lcsh:RD1-811 medicine.disease Surgery medicine.anatomical_structure Rectal Diseases Treatment Outcome 030220 oncology & carcinogenesis Sphincter 030211 gastroenterology & hepatology Collagen business Organ Sparing Treatments |
| Zdroj: | Asian Journal of Surgery, Vol 43, Iss 2, Pp 401-404 (2020) |
| ISSN: | 0219-3108 |
| Popis: | Summary: Background: Fistula-in-ano is one of the most commonly presenting anorectal diseases. Sphincter sparing treatment options should be considered in patients with complex fistulas. Salvecoll-E gel is a native collagen deantigenated and purified, non-cross-linked equine dermal extract, with an amino acid composition identical to human collagen. Methods: The multicentric trial study was a prospective, single-arm observational clinical study with the objective to assess the efficacy of Salvecoll-E gel for anal fistula repair in 70 patients. All patients had undergone preliminary surgical treatment consisting of positioning of a draining loosing seton that was maintained for a period of 4–6 weeks. After seton removal, a gentle debridement and washing of the fistula track was performed. The scar tissue was removed from the internal orifice. Internal opening was covered by a side-to side mucosal suture. Salvecoll-E was injected through the external opening into the fistula track, the external opening it has been opened. Results: Twelve months after surgery, 55 patients demonstrated a clinically healed fistula (78,5%), 15 patients have a recurrence (21,5%). Most of the recurrences were observed in the first 6 months of treatment (13/15, 86.6%). We don't observe any worsening in CCF score. The results obtained at 1 year certainly seem satisfactory and in line with the best results published in literature using mini-invasive techniques. Conclusion: Salvecoll-E gel is a promising non-invasive technique for conservative treatment of anal fistulas, it's well tolerated by the patients and, in case of recurrence, reinjection or all other known techniques are feasible. Keywords: Complex ano-rectal fistula, Non cutting technique, Mini-invasive treatment |
| Databáze: | OpenAIRE |
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