Palatability Can Drive Feeding Independent of AgRP Neurons
| Autor: | Pascal Verdié, Michael J. Krashes, Raphael G. P. Denis, Aurélie Joly-Amado, Thomas S. Hnasko, Claude Rouch, Amélie Lacombe, Fanny Langlet, Céline Cansell, E.S. Webber, Marie Schaeffer, Jean-Alain Fehrentz, Sarah Martinez, Ali D. Güler, Serge Luquet, Jean Martinez, Richard D. Palmiter, Bénédicte Dehouck, Stephanie L Padilla, Nadim Kassis, Julien Castel, Christophe Magnan, Anne Sophie Delbès |
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| Přispěvatelé: | Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health [Bethesda] (NIH), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), University of Washington [Seattle], Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), University of California [San Diego] (UC San Diego), University of California, University of Virginia [Charlottesville], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), National Institute of Diabetes and Digestive and Kidney Diseases [Bethesda], Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), University of California (UC), University of Virginia, KARLI, Mélanie |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
030309 nutrition & dietetics
Physiology Dopamine [SDV]Life Sciences [q-bio] Medical Biochemistry and Metabolomics Inbred C57BL Eating Mice 0302 clinical medicine Agouti-Related Protein Palatability Mice Knockout Neurons 0303 health sciences digestive oral and skin physiology [SDV] Life Sciences [q-bio] medicine.anatomical_structure Hypothalamus Neurological Ghrelin medicine.symptom hormones hormone substitutes and hormone antagonists medicine.drug Signal Transduction Knockout Anorexia Biology Basic Behavioral and Social Science Article Endocrinology & Metabolism 03 medical and health sciences Orexigenic Behavioral and Social Science medicine Biological neural network Animals Obesity Molecular Biology Nutrition 030304 developmental biology Neurosciences Cell Biology Mice Inbred C57BL nervous system Biochemistry and Cell Biology Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell Metabolism Cell Metabolism, Elsevier, 2015, 22 (4), pp.646-657. ⟨10.1016/j.cmet.2015.07.011⟩ Cell Metabolism, 2015, 22 (4), pp.646-657. ⟨10.1016/j.cmet.2015.07.011⟩ Cell metabolism, vol 22, iss 4 |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2015.07.011⟩ |
| Popis: | International audience; Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake--a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling. |
| Databáze: | OpenAIRE |
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