Argyrophilic grain disease presenting as behavioral frontotemporal dementia
| Autor: | María Sagrario Manzano, Soledad Serrano, Alberto Rábano, María L. Cuadrado, María José Gil, Elena Góméz |
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| Rok vydání: | 2019 |
| Předmět: |
Male
endocrine system Pathology medicine.medical_specialty Autopsy Disease Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Neuroimaging mental disorders medicine Humans Cognitive impairment Aged business.industry General Medicine medicine.disease Tauopathies Neurology Argyrophilic grain disease Frontotemporal Dementia Neurology (clinical) Tauopathy Differential diagnosis business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Clinical Neuropathology. 38:8-13 |
| ISSN: | 0722-5091 |
| DOI: | 10.5414/np301122 |
| Popis: | Argyrophilic grain disease (AgD) is a frequent late-onset 4R tauopathy of old age characterized by the presence of profuse spindle-shaped argyrophilic grains (AGs). It is a neurodegenerative disorder that is clinically characterized by a slow progressive amnestic mild cognitive impairment similar to Alzheimer's disease. In rare instances, it is characterized as a behavioral-variant frontotemporal dementia (bv-FTD). In this study, we report a case with typical clinical and neuroimaging features of bv-FTD, who had autopsy findings consistent with a definitive diagnosis of AgD. We suggest that AgD might be included in the differential diagnosis of patients presenting with bv-FTD. . |
| Databáze: | OpenAIRE |
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