Translational Potential of Metabolomics on Animal Models of Inflammatory Bowel Disease—A Systematic Critical Review

Autor:	Signe Bek Sørensen, Rasmus Desdorf, Sören Möller, Vibeke Andersen, Axel Kornerup Hansen, Lina Almind Knudsen
Rok vydání:	2020
Předmět:	0301 basic medicine Review Disease Gut flora Bioinformatics Inflammatory bowel disease lcsh:Chemistry Translational Research Biomedical Mice 0302 clinical medicine systematic review lcsh:QH301-705.5 Spectroscopy biology Sodium Dodecyl Sulfate General Medicine metabolomics animal models Human situation Animal models Computer Science Applications Metabolome 030211 gastroenterology & hepatology Animal studies MEDLINE Catalysis Inorganic Chemistry 03 medical and health sciences Metabolomics inflammatory bowel disease medicine Animals Humans Physical and Theoretical Chemistry Molecular Biology business.industry Organic Chemistry Inflammatory Bowel Diseases medicine.disease biology.organism_classification digestive system diseases Disease Models Animal 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Systematic review business
Zdroj:	Knudsen, L A, Desdorf, R, Möller, S, Sørensen, S B, Hansen, A K & Andersen, V 2020, ' Translational potential of metabolomics on animal models of inflammatory bowel disease : a systematic critical review ', International Journal of Molecular Sciences, vol. 21, no. 11, 3856 . https://doi.org/10.3390/ijms21113856 International Journal of Molecular Sciences Knudsen, L A, Desdorf, R, Möller, S, Sørensen, S B, Hansen, A K & Andersen, V 2020, ' Translational Potential of Metabolomics on Animal Models of Inflammatory Bowel Disease : A Systematic Critical Review ', International Journal of Molecular Sciences, vol. 21, no. 11, 3856 . https://doi.org/10.3390/ijms21113856 International Journal of Molecular Sciences, Vol 21, Iss 3856, p 3856 (2020)
ISSN:	1422-0067
DOI:	10.3390/ijms21113856
Popis:	In the development of inflammatory bowel disease (IBD), the gut microbiota has been established as a key factor. Recently, metabolomics has become important for understanding the functional relevance of gut microbial changes in disease. Animal models for IBD enable the study of factors involved in disease development. However, results from animal studies may not represent the human situation. The aim of this study was to investigate whether results from metabolomics studies on animal models for IBD were similar to those from studies on IBD patients. Medline and Embase were searched for relevant studies up to May 2017. The Covidence systematic review software was used for study screening, and quality assessment was conducted for all included studies. Data showed a convergence of ~17% for metabolites differentiated between IBD and controls in human and animal studies with amino acids being the most differentiated metabolite subclass. The acute dextran sodium sulfate model appeared as a good model for analysis of systemic metabolites in IBD, but analytical platform, age, and biological sample type did not show clear correlations with any significant metabolites. In conclusion, this systematic review highlights the variation in metabolomics results, and emphasizes the importance of expanding the applied detection methods to ensure greater coverage and convergence between the various different patient phenotypes and animal models of inflammatory bowel disease.
Databáze:	OpenAIRE
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