Arabidopsis Target of Rapamycin Coordinates With Transcriptional and Epigenetic Machinery to Regulate Thermotolerance
| Autor: | Sanjeet Kumar Mahtha, Gitanjali Yadav, Brihaspati N. Shukla, Manvi Sharma, Muhammed Jamsheer K, Ashverya Laxmi, Mohan Sharma, Prakhar Awasthi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Regulation of gene expression
biology epigenetics Plant culture Plant Science CREB biology.organism_classification Cell biology SB1-1110 Transcriptome heat stress Histone climate change Transcription (biology) Arabidopsis biology.protein Epigenetics glucose gene regulation Reprogramming TOR-E2Fa signalling Original Research |
| Zdroj: | Frontiers in Plant Science Frontiers in Plant Science, Vol 12 (2021) |
| ISSN: | 1664-462X |
| Popis: | Global warming exhibits profound effects on plant fitness and productivity. To withstand stress, plants sacrifice their growth and activate protective stress responses for ensuring survival. However, the switch between growth and stress is largely elusive. In the past decade, the role of the target of rapamycin (TOR) linking energy and stress signalling is emerging. Here, we have identified an important role of Glucose (Glc)-TOR signalling in plant adaptation to heat stress (HS). Glc via TOR governs the transcriptome reprogramming of a large number of genes involved in heat stress protection. Downstream to Glc-TOR, the E2Fa signalling module regulates the transcription of heat shock factors through direct recruitment of E2Fa onto their promoter regions. Also, Glc epigenetically regulates the transcription of core HS signalling genes in a TOR-dependent manner. TOR acts in concert with p300/CREB HISTONE ACETYLTRANSFERASE1 (HAC1) and dictates the epigenetic landscape of HS loci to regulate thermotolerance. Arabidopsis plants defective in TOR and HAC1 exhibited reduced thermotolerance with a decrease in the expression of core HS signalling genes. Together, our findings reveal a mechanistic framework in which Glc-TOR signalling through different modules integrates stress and energy signalling to regulate thermotolerance. |
| Databáze: | OpenAIRE |
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