Effect of cell-phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells
| Autor: | Gerald Batist, Amber Yasmeen, Alaaeldin Saleh, Yaman M AlAhmad, Mohammed Aljaber, Ala-Eddin Al Moustafa, Huseyin C. Yalcin, Tahar Aboulkassim |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
cell phone Angiogenesis Radio Waves Cell Down-Regulation Chorioallantoic Membrane 03 medical and health sciences angiogenesis 0302 clinical medicine radiofrequency Downregulation and upregulation Western blot Cell Line Tumor medicine Humans Neoplasm Invasiveness Erk1/Erk2 Cell invasion Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 medicine.diagnostic_test Neovascularization Pathologic business.industry Head and neck cancer medicine.disease cell invasion Cadherins cancer progression Enzyme Activation Chorioallantoic membrane 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Cancer cell Cancer research business Cell Phone |
| Zdroj: | Headneck. 40(10) |
| ISSN: | 1097-0347 |
| Popis: | Today, the cell phone is the most widespread technology globally. However, the outcome of cell-phone radiofrequency on head and neck cancer progression has not yet been explored. The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell-phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E-cadherin and Erk1/Erk2 genes. Our data revealed that cell-phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E-cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models. Our investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation. This work was supported by Qatar University and GCC grant #2017‐002 QU/KU |
| Databáze: | OpenAIRE |
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