Histone Acetylation and Reactivation of Epstein-Barr Virus from Latency
| Autor: | Ulrich K. Binné, Peter J. Jenkins, Paul J. Farrell |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Gene Expression Regulation
Viral Herpesvirus 4 Human viruses Molecular Sequence Data Immunology medicine.disease_cause Microbiology Cell Line Histones Viral Proteins hemic and lymphatic diseases Virology Virus latency medicine Humans Promoter Regions Genetic Regulation of gene expression Base Sequence biology Acetylation biochemical phenomena metabolism and nutrition medicine.disease Molecular biology Epstein–Barr virus Chromatin Virus-Cell Interactions Clone Cells Virus Latency BZLF1 DNA-Binding Proteins Histone Lytic cycle Insect Science DNA Viral Trans-Activators biology.protein Virus Activation |
| Zdroj: | Journal of Virology. 74:710-720 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.74.2.710-720.2000 |
| Popis: | Induction of the viral BZLF1 gene has previously been shown to be one of the first steps in the reactivation of Epstein-Barr virus (EBV). Using an EBV oriP episomal vector system, we have reconstituted the regulation of the promoter for BZLF1 on stably transfected episomes, mapped promoter elements required for that regulation, and investigated mechanisms that may control the switch between latency and the lytic cycle. Changes in histone acetylation at the promoter for the BZLF1 gene appear to be a key part of the reactivation mechanism of this herpesvirus. |
| Databáze: | OpenAIRE |
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