Managing anovulatory infertility and polycystic ovary syndrome
| Autor: | Adam H. Balen, Anthony J. Rutherford |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Infertility
Clinical Review medicine.medical_specialty medicine.medical_treatment Reproductive medicine Anovulation Ovulation Induction medicine Humans Hypoglycemic Agents Obesity hirsutism General Environmental Science Gynecology Obstetrics business.industry Female infertility Hyperandrogenism General Engineering General Medicine medicine.disease Polycystic ovary Metformin General Earth and Planetary Sciences Female Ovulation induction business Infertility Female Polycystic Ovary Syndrome |
| Zdroj: | BMJ. 335:663-666 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.39335.462303.80 |
| Popis: | In this second overview of the current management of infertility we discuss anovulatory infertility and polycystic ovary syndrome. This syndrome (formerly known as Stein-Leventhal syndrome) is the most common hormonal disturbance in women—around one fifth of women in the United Kingdom are affected. It is also the most common reason for women not to ovulate, and the combination of being overweight and having polycystic ovary syndrome can have a profound effect on reproductive health. #### Summary points We referred to the Cochrane database of systematic reviews, The National Institute for Health and Clinical Excellence (NICE) guidelines for the investigation and management of infertility (2004), and our knowledge of the current literature. Anovulation is the cause of infertility in about a third of couples attending infertility clinics, and polycystic ovary syndrome accounts for 90% of such cases.1 Once tests have excluded other causes of androgen excess and menstrual disturbance, the syndrome can be confirmed by the presence of two of the following criteria— biochemical or clinical hyperandrogenism (hirsutism, acne, or alopecia); menstrual irregularity; and polycystic ovaries (figure⇓).2 Symptoms, signs, and biochemical features vary greatly among affected women and may change over time in individual women.3 This review will concentrate on the management of infertility. The general practitioner should be able to start investigations and formulate a diagnosis before referral to a specialist in reproductive medicine. Three dimensional ultrasound scan of a polycystic ovary (centre) showing multiple cysts … |
| Databáze: | OpenAIRE |
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